Ashok Kumar Chauhan
Postgraduate Institute of Medical Sciences Rohtak, Haryana, India.
Title: Chemoradiation Alongwith Curcumin in the management of Uterine Cervical Cancer
Biography
Biography: Ashok Kumar Chauhan
Abstract
Introduction: Th e cervical cancer is the most common gynaecological cancer in the developing countries and leading cause of cancer related mortality in women globally. Th e majority of the women in the under developed and developing nations present in locally advanced stages. Th e combination of radiation and chemotherapy is the standard of care in locally advanced cervical cancer. However, the toxicity is a matter of concern. So attempt has been made in this prospective study to use curcumin as radiosensitizer and at the same time as protector of the normal tissues. Material and Methods: Th e study has been conducted in 80 women having stages of IIB to IVA by randomly dividing them in two groups. Th e patients of both the groups received External Beam Radiotherapy with dose of 50 Gy in 25 Fractions along with Cisplatin 40mg/m2 weekly for fi ve weeks. Th is was followed by three fractions of High Dose Rate brachytherapy with a dose of 6 Gy per fraction. Th e patients of group-I only received Curcumin 4gm per day Results: Aft er six weeks of completion of treatment the patients were evaluated for response to treatment as per WHO criteria. Th ere was complete response in 72% in group-I and 66% in group-II. Th e patients who received curcumin experienced less cutaneous and mucosal reactions. Th e patients have been followed up for 4 years. Conclusions: Th e follow-up at 4 years of follow-up shows advantage for those treated with curcumin in terms of overall survival