Day :
- Polycystic ovary syndrome (PCOS) |Gynecology and Infectious disease | Cervical Cancer |Urogynecology and Contraception | Assisted Reproductive Technology(ART) |Reproductive Medicine| In vitro Fertilisation (IVF) | Women Reproductive Cancers
Location: Norway
Session Introduction
David Ling
Stanford University Palo Alto, USA
Title: Intrauterine local anesthesia
Biography:
David Ling from USA has done his Education at Stanford University Palo Alto CA, USA, University of Louisville School of Medicine Louisville KY USA, University of Louisville MS Pharmacology and his Graduation Medical Education at Cook County Hospital, Chicago and also a rotating intern from 1964 to 1965. He also worked at Northwestern University Medical School as s Clinical Instructor from 1972 to 1976.
Abstract:
The first local anesthetic to be discovered was cocaine an alkaloid in large amount (0.6 to 1.8%) on the leaves of Erythroxylon coca a shrub growing in the Andes Mountains. Vast quantities were consumed orally and annually. The plant ash when chewed releases the plant alkaloid and absorbed across the mouth mucous membrane. In 1880 Niemann noted that the tongue was numb with no sensation upon chewing this substance. It is well known that Lidocaine was absorbed across the mucous membrane. Anesthesia for gynecological surgery procedure is not very satisfactory in certain aspects. General anesthesia is excellent but it involves the services of a anesthesiologist in the hospital. Paracervical block uses from 10 to 18 cc of 1% Lidocaine a relatively large amount. The VAS score from the block itself is between 19 to 69 mm. A quoted study showed that paracervical block does not significantly decrease pain with IUD insertion.
Study Design: This is a retroactive study comparing patients with gynecological procedure without any anesthesia and with ° intrauterine 1% Lidocaine injected into the uterine cavity. Pain was evaluated with the VAS score at 1. Instrument insertion, 2. Actual procedure and 3. 5 minutes post operation. The procedures include 1. IUD insertion, 2. SIS, 3. Endometrial biopsy, 4. D&C. Others such as IUI , sterilization etc may also be included. ,
Results: After 3-5 cc of 1% Lidocaine injection into the uterine cavity, the median VAS score is only about 5 mm. On testing serum Lidocaine at 5 minutes after injection the serum level is below 1.5 mg/L. Our normal Lidocaine therapeutic level is 1.5 to 5 mg/L. Without anesthesia the VAS score is about 75 mm. Conclusion: Injecting 3-5 cc of 1% Lidocaine into the uterus results in very good anesthesia. Knowing the serum level is below 1.5 mg/L this procedure can be used with impunity.
Yihui Feng
Guangzhou University of Chinese Medicine, China
Title: Hsa_circ_0000376: A potential novel biomarker for the prediction of primary ovarian insufficiency
Biography:
Ying Zhao has completed her PhD, is the Professor of Obstetrics and Gynecology in the Guangzhou University of Chinese Medicine. She is also the Director of the Center for Women’s Health Research and an expert in using Chinese Medicine as the treatment for Reproductive Disorders. She has published 49 papers in reputed journals, which focused on her specialties: Reproductive Endocrinology and Infertility, Gynecology. She has been the Leader in several research programs, which funded by the National Natural Science Foundation of China.
Abstract:
Background: Primary ovarian insuff iciency (POI) is a reproductive disorder occurs to women before 40 years old, which affects their fertility and life quality. However, the mechanisms of POI remain largely unknown, approximately 50% accordingly. Circular RNAs (circRNAs) have recently been implicated in ovarian aging, but their potential as biomarkers was never investigated in POI. Herein, this study aimed to identify the role of circRNAs as a potential biomarker in POI patients.
Methods: CircRNA expression screening was performed in plasma RNA from f ive pairs of POI patients and age- and sex-matched controls using circRNA microarray. In the validation phase, 18 circRNA candidates were validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) in a cohort of 25 patients diagnosed with POI and 25 age- and sample storage time- matched controls.
Results: Of 6644 differentially expressed circRNAs, 12 signif icantly up- regulated and 23 signif icantly down-regulated circRNAs were identif ied in the POI patients compared with the control group, which showed as red points in the volcano plot analysis (p<0.05, fold change>1.5). Based on the evaluation of initial expression quantity and fold change values, 18 circRNAs candidates were selected for the validation phase. Hsa_circ_0000376 was significantly downregulated in POI patients compared with the control group in qRT-PCR (P <0.05). The area under the ROC curve (AUC) of hsa_circ_0000376 was 0.698 (95% CI 0.499-0.897). The sensitivity and specificity at the cutoff value of 0.685 were 73.3% and 60%, respectively. Conclusion: Taken together, our study indicates that hsa_circ_0000376 may play potential roles in predicting POI.
Jane Viola Namullindwa
Masaka Regional Referral Hospital, Uganda
Title: Non-technological ways of improving women's health in under privileged areas
Biography:
Tremendous growth has been achieved over the years in various fields of medicine. New and advanced approaches have been and are being made towards the improvement of women’s health as well as the health of mankind as a whole. However, not all problems need technology as solutions. Women’s health as a whole is determined by various factors which include; social, economic, spiritual and political factors to mention but a few. In most of the less privileged communities, awareness is still an issue. Despite the increased access and use of smart phones, people are still inadequately informed about basic and essential health care needs and services available. This calls for more vigorous and in depth spread of basic health care information to the deepest of communities through other means for example through village health talks, use of community speakers, radio health talks, on contact with health workers. In addition, wrong information being passed on as the right information by less or unqualified health personnel especially in private clinics situated in rural areas is still an issue. This calls for governments to strongly enforce the already existing regulations on health practice in their countries. This will help to reduce myths and misconceptions on different women’s health care needs and services available. Furthermore, cultural practices also majorly contribute to the setbacks on our progress in improving women’s health. Traditions like men not escorting their wives in seeking health care services is one of the many. In most rural communities, wives need consent from their husbands to make some health care service decisions for example family planning. This causes another delay on top of the already existing delays hence slowing the use of the available health care services. In conclusion, different factors greatly affect the progress and implementation of global developments and thus, should be worked upon for a faster and easier improvement in women’s health
Abstract:
Jane Viola Namullindwa has completed her internship programme from Masaka Regional Referral Hospital in Masaka Uganda. She has completed her Medicine course from Makerere Medical School last year and therefore is still fresh Medical officer but motivated to do maternal health and child survival career.